Synthesis and Antimicrobial Activity of Some Novel Heterocyclic Candidates via Michael Addition Involving 4-(4-Acetamidophenyl)-4-oxobut-2-enoic Acid

This paper discusses the utility of 4-(4-acetamidophenyl)-4-oxobut-2-enoic acid as a key starting material for the preparation of a novel series of pyridazinones, thiazoles derivatives, and other heterocycles via interaction with nitrogen, sulfur, and carbon nucleophiles under Michael addition condi...

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Bibliographic Details
Published in:Advances in Chemistry 2014-09, Vol.2014, p.1-10
Main Authors: EL-Hashash, Maher A., Essawy, A., Sobhy Fawzy, Ahmed
Format: Article
Language:English
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Summary:This paper discusses the utility of 4-(4-acetamidophenyl)-4-oxobut-2-enoic acid as a key starting material for the preparation of a novel series of pyridazinones, thiazoles derivatives, and other heterocycles via interaction with nitrogen, sulfur, and carbon nucleophiles under Michael addition conditions and studies the antimicrobial activities of some of these compounds.
ISSN:2356-6612
2314-7571
DOI:10.1155/2014/619749