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Protective Effect of Hedeoma drummondii against Formaldehyde-Induced Testicular Toxicity and Genotoxicity in Wistar Rats
Formaldehyde (FA) is an oxidative stress inducer and a known carcinogen. Hedeoma drummondii has been shown to have potential as a chemopreventive agent. The aim of this study was to assess the protective effect of H. drummondii on FA-induced genotoxic damage, sperm quality parameters, and histologic...
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Published in: | Andrologia 2023-10, Vol.2023, p.1-10 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Formaldehyde (FA) is an oxidative stress inducer and a known carcinogen. Hedeoma drummondii has been shown to have potential as a chemopreventive agent. The aim of this study was to assess the protective effect of H. drummondii on FA-induced genotoxic damage, sperm quality parameters, and histological changes of the testis. The male Wistar rats used were divided into the following groups: (G1) 100 mg/kg H. drummondii; (G2) 10 mg/kg FA; (G3) 100 mg/kg H. drummondii + 10 mg/kg FA; (G4) phosphate-buffered saline; (G5) 100 mg/kg α-tocopherol; (G6) 100 mg/kg α-tocopherol + 10 mg/kg FA; and (G7) soybean oil. The results showed a sperm concentration of 23.66 ± 1.52 versus 33.67 cells/mL (p=0.02), and a percentage of motility of 29.66 ± 1.51 versus 33.33 (p=0.620), for groups G3 and G6, respectively. Histopathological (H&E) and immunohistochemical analysis of superoxide dismutase showed damage in the germinal epithelium (GE) in G2. While in groups G3 and G6, the histological structure was preserved. A protective effect on sperm DNA fragmentation was also observed for treated groups (G3 and G6, p |
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ISSN: | 0303-4569 1439-0272 |
DOI: | 10.1155/2023/6631345 |