Synthesis and Characterization of Coordinatively Unsaturated Copper(II) Complexes of 1,3‐Bis(2′‐Pyridyl)‐1,2‐Diaza‐2‐Butene and TheirAntityrosinase Activity

The coordinatively unsaturated copper (II) complexes of 1,3‐bis(2′‐pyridyl)‐1,2‐diaza‐2‐ butene with different ancillary anions were synthesized which can bind to copper centers of tyrosinase enzyme. The compounds were found to exhibit inhibitory activities against mushroom tyrosinase and the nature...

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Bibliographic Details
Published in:Metal-based drugs 1998-01, Vol.5 (2), p.59-66
Main Authors: Bendre, Ratnamala, Murugkar, Anupa, Padhye, Subhash, Kulkarni, Pallavi, Karve, Meena
Format: Article
Language:English
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Summary:The coordinatively unsaturated copper (II) complexes of 1,3‐bis(2′‐pyridyl)‐1,2‐diaza‐2‐ butene with different ancillary anions were synthesized which can bind to copper centers of tyrosinase enzyme. The compounds were found to exhibit inhibitory activities against mushroom tyrosinase and the nature and extent of inhibition is modulated according to the type of ancillary anions.
ISSN:0793-0291
1687-5486
DOI:10.1155/MBD.1998.59