Synthesis and Characterization of Coordinatively Unsaturated Copper(II) Complexes of 1,3‐Bis(2′‐Pyridyl)‐1,2‐Diaza‐2‐Butene and TheirAntityrosinase Activity

The coordinatively unsaturated copper (II) complexes of 1,3‐bis(2′‐pyridyl)‐1,2‐diaza‐2‐ butene with different ancillary anions were synthesized which can bind to copper centers of tyrosinase enzyme. The compounds were found to exhibit inhibitory activities against mushroom tyrosinase and the nature...

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Published in:Metal-based drugs 1998-01, Vol.5 (2), p.59-66
Main Authors: Bendre, Ratnamala, Murugkar, Anupa, Padhye, Subhash, Kulkarni, Pallavi, Karve, Meena
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Language:English
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container_issue 2
container_start_page 59
container_title Metal-based drugs
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creator Bendre, Ratnamala
Murugkar, Anupa
Padhye, Subhash
Kulkarni, Pallavi
Karve, Meena
description The coordinatively unsaturated copper (II) complexes of 1,3‐bis(2′‐pyridyl)‐1,2‐diaza‐2‐ butene with different ancillary anions were synthesized which can bind to copper centers of tyrosinase enzyme. The compounds were found to exhibit inhibitory activities against mushroom tyrosinase and the nature and extent of inhibition is modulated according to the type of ancillary anions.
doi_str_mv 10.1155/MBD.1998.59
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title Synthesis and Characterization of Coordinatively Unsaturated Copper(II) Complexes of 1,3‐Bis(2′‐Pyridyl)‐1,2‐Diaza‐2‐Butene and TheirAntityrosinase Activity
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