A comparison of the Antileukaemic Effects of Recombinant HumanTumour Necrosis Factor‐α and its Muteins on Leukaemia L1210 and Leukaemia P388 in Mice

We investigated the influence of recombinant human tumour necrosis factor alpha (TNF‐α) and its derivatives termed muteins III, V, VI—in which the first 3 to 7 amino acids of native TNF‐α have been replaced—on the survival time of mice inoculated with leukaemia L1210 or leukaemia P338. TNF‐α prolong...

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Bibliographic Details
Published in:Mediators of inflammation 1994-01, Vol.3 (6), p.411-414
Main Authors: Warzocha, K., Góra-Tybor, J., Kwinkowski, M., Szymańska, B., Robak, T.
Format: Article
Language:English
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Summary:We investigated the influence of recombinant human tumour necrosis factor alpha (TNF‐α) and its derivatives termed muteins III, V, VI—in which the first 3 to 7 amino acids of native TNF‐α have been replaced—on the survival time of mice inoculated with leukaemia L1210 or leukaemia P338. TNF‐α prolonged the survival of mice with leukaemia L1210 but did not have any therapeutic activity in leukaemia P388‐bearing mice. Muteins‐treated mice with leukaemia P388 lived longer than animals receiving TNF‐α, while those inoculated with leukaemia L1210 did not show any significant prolongation of life compared with the TNF‐α treated group. The results presented in this report indicate that the antileukaemic activity of TNF‐α is governed at least in part by the nature of the N‐terminal amino acids.
ISSN:0962-9351
1466-1861
DOI:10.1155/S0962935194000578