Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation

Oral retinoids can reduce basal cell carcinoma (BCC) incidence in genetically susceptible patients, and one topical retinoid, tazarotene, has been reported to cure some sporadic BCCs. Therefore, we have tested whether this agent would affect BCCs in Ptch1+/- mice in a controlled chemoprevention tria...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2004-07, Vol.64 (13), p.4385-4389
Main Authors: So, Po-Lin, Lee, Kenneth, Hebert, Jennifer, Walker, Patricia, Lu, Ying, Hwang, Jimmy, Kopelovich, Levy, Athar, Mohammed, Bickers, David, Aszterbaum, Michelle, Epstein, Jr, Ervin H
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Anticarcinogenic Agents - administration & dosage
Carcinoma, Basal Cell - etiology
Carcinoma, Basal Cell - genetics
Carcinoma, Basal Cell - prevention & control
Female
Genetic Predisposition to Disease
Intracellular Signaling Peptides and Proteins
Male
Membrane Proteins
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Neoplasms, Radiation-Induced - etiology
Neoplasms, Radiation-Induced - genetics
Neoplasms, Radiation-Induced - prevention & control
Nicotinic Acids - administration & dosage
Patched Receptors
Patched-1 Receptor
Proteins - genetics
Receptors, Cell Surface
Skin Neoplasms - etiology
Skin Neoplasms - genetics
Skin Neoplasms - prevention & control
Ultraviolet Rays - adverse effects
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Summary:Oral retinoids can reduce basal cell carcinoma (BCC) incidence in genetically susceptible patients, and one topical retinoid, tazarotene, has been reported to cure some sporadic BCCs. Therefore, we have tested whether this agent would affect BCCs in Ptch1+/- mice in a controlled chemoprevention trial. We found that topical tazarotene dramatically inhibits the formation of BCCs induced with either UV or ionizing radiation. The ability of tazarotene to inhibit BCC formation in this mouse model provides encouragement for the use of tazarotene in skin cancer chemoprevention trials in humans.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-03-1927