Genomic Profiling of Breast Cancer (BC) in Mali by Oligonucleotide Comparative Genomic Hybridization (CGH) Array

• Published in: Cancer research (Chicago, Ill.) Ill.), 2009-12, Vol.69 (24_Supplement), p.3059-3059
• Main Authors: Ly, M., Diallo, G., Valente, A., Diallo, D., Dumke, K., Marty, V., Scott, V., Pusztai, L., Berrada, N., Lazar, V., Job, B., Viehl, P., Bernaudin, J., André, F.
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/0008-5472.SABCS-09-3059

Background: Epidemiological studies suggest that BC in Africa exhibit specific biological characteristics as compared to BC from US/Europe. In order to identify therapeutic targets that would be specific from Africa, we analyzed 28 samples from Mali by high resolution CGH array, and compared gene gains/losses to the ones observed in USA [André F et al, Clin Cancer Res, 2009]Patients and methods: 71 paraffin-embedded samples of invasive BC from patients treated by surgery at Bamako were retrieved, 28 of them (from 2 pts stage 1; 13 pts stage 2; 11 pts stage 3 and 2 pts stage 4) were eligible for CGH array (1) (Agilent, 4*44K) (cancer cells>50%; undamaged DNA >1µg).Results were compared to 106 samples from MD Anderson, profiled in the sample genomic platform using the same array (1)Results: The median age was 49 year old. Twenty-one samples (75%) were ER-negative. No difference was observed regarding the frequency of gene gains in 17q12-21 (ERBB2) nor 8p11-12 (FGFR1). Six regions were more frequently gained in BC from Mali, as compared to those from US (FDR