Circulating Endogenous Retinoic Acid Concentrations among Participants Enrolled in a Randomized Placebo-Controlled Clinical Trial of Retinyl Palmitate

Retinoids have been studied extensively for their chemopreventive properties. The biological activity of retinoids is acquired through their conversion to retinoic acid (RA). Characterization of endogenous circulating RA concentrations after supplementation with vitamin A over longer time periods ha...

Full description

Saved in:
Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2004-11, Vol.13 (11), p.1687-1692
Main Authors: SEDJO, Rebecca L, RANGER-MOORE, James, FOOTE, Janet, CRAFT, Neal E, ALBERTS, David S, XU, Min-Jian, GIULIANO, Anna R
Format: Article
Language:English
Subjects:
Aged
Anticarcinogenic Agents - administration & dosage
Anticarcinogenic Agents - metabolism
Anticarcinogenic Agents - therapeutic use
Antineoplastic agents
Biological and medical sciences
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
Female
General aspects
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Randomized Controlled Trials as Topic
Skin Neoplasms - prevention & control
Stereoisomerism
Tretinoin - blood
Vitamin A - administration & dosage
Vitamin A - analogs & derivatives
Vitamin A - metabolism
Vitamin A - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Retinoids have been studied extensively for their chemopreventive properties. The biological activity of retinoids is acquired through their conversion to retinoic acid (RA). Characterization of endogenous circulating RA concentrations after supplementation with vitamin A over longer time periods has not been done previously. Our investigation was conducted to determine whether vitamin A (retinyl palmitate) supplementation significantly increases circulating RA concentrations of all- trans -, 9- cis -, and 13- cis -RA. Using plasma samples from 41 participants enrolled in a randomized clinical trial of placebo, 25,000, 50,000, or 75,000 IU supplemental retinyl palmitate daily, high-performance liquid chromatography analyses were conducted for concentrations of three RA isomers. Seven plasma samples were analyzed for each participant over a 16-month period. Based on an intention-to-treat analysis, results obtained using linear mixed models showed that supplementation with retinyl palmitate statistically significantly increased concentrations of all three RA isomers from baseline levels. This study suggests that supplementation with retinyl palmitate is an effective means to increase circulating all- trans , 9- cis -, and 13- cis -RA concentrations among humans.
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.1687.13.11