Abstract A4: Integrative genomic analysis of lung cancer: Focus on health disparities

• Published in: Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2011-09, Vol.20 (10_Supplement), p.A4-A4
• Main Authors: Robles, Ana I., Mathé, Ewy, Bowman, Elise D., Ryan, Brid M., Haznadar, Majda, Harris, Curtis C.
• Format: Article
• Language: English
• ISSN: 1055-9965; 1538-7755
• DOI: 10.1158/1055-9965.DISP-11-A4

Racial differences in the incidence and mortality of lung cancer are well documented. Many factors are known to influence the risk and outcome of this most deadly disease, including exposure, behavior, access to health care, as well as inherent susceptibility. There is a paucity of data regarding the existence, if any, of biological differences among tumors that reflect inherent susceptibilities to known etiological factors and may contribute to some of the disparities observed among African Americans and Caucasians. Our laboratory employs a multipronged strategy to study the interaction of genetic, molecular, and etiological factors leading to lung cancer risk and survival, that encompasses mRNA and microRNA (miRNA) expression, DNA methylation, metabolomics, as well as genetic susceptibility in the form of Single Nucleotide Polymorphisms (SNPs). In this study, a cohort of sixty paired cancerous/non-cancerous lung tissues excised from stage I lung cancer patients (16 African Americans and 48 Caucasians) recruited through our longstanding Case-Control Study at University of Maryland, Baltimore, are being characterized by miRNA quantitation (Nanostring nCounter Human miRNA Expression Assay), mRNA expression profiling (Illumina HumanRef-8 v3 Expression Beadchip arrays), and methylation profiling (Illumina Infinium Human Methylation27 Beadchip arrays). When gene expression profiles on cancerous tissues from African Americans and Caucasians were compared, three genes were differentially expressed (FDR