Lessons Learned from Setting Up a Prospective, Longitudinal, Multicenter Study with Women at High Risk for Breast Cancer

Women identified with an increased risk of breast cancer due to mutations in cancer susceptibility genes or a familial history of breast cancer undergo tailored screening with the goal of detecting tumors earlier, when potential curative interventions are still possible. Ideally, screening would ide...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2021-03, Vol.30 (3), p.441-449
Main Authors: Patuleia, Susana I S, Hagenaars, Sophie C, Moelans, Cathy B, Ausems, Margreet G E M, van Gils, Carla H, Tollenaar, Rob A E M, van Diest, Paul J, Mesker, Wilma E, van der Wall, Elsken
Format: Article
Language:English
Subjects:
Breast Neoplasms - diagnosis
Breast Neoplasms - epidemiology
Female
Humans
Longitudinal Studies
Mass Screening - methods
Multicenter Studies as Topic
Prospective Studies
Risk Factors
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Summary:Women identified with an increased risk of breast cancer due to mutations in cancer susceptibility genes or a familial history of breast cancer undergo tailored screening with the goal of detecting tumors earlier, when potential curative interventions are still possible. Ideally, screening would identify signs of carcinogenesis even before a tumor is detectable by imaging. This could be achieved by timely signaling of altered biomarker levels for precancerous processes in liquid biopsies. Currently, the Nipple Aspirate Fluid (NAF) and the Trial Early Serum Test BREAST cancer (TESTBREAST), both ongoing, prospective, multicenter studies, are investigating biomarkers in liquid biopsies to improve breast cancer screening in high-risk women. The NAF study focuses on changes over time in miRNA expression levels both in blood and NAF samples, whereas the TESTBREAST study analyzes changes in protein levels in blood samples at sequential interval timepoints. These within-subject changes are studied in relation to later occurrence of breast cancer using a nested case-control design. These longitudinal studies face their own challenges in execution, such as hindrances in logistics and in sample processing that were difficult to anticipate. This article offers insight into those challenges and concurrently aims to provide useful strategies for the set-up of similar studies. .
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-20-0770