Low Levels of Alcohol Consumption and Risk of Intestinal Metaplasia: A Cohort Study

The impact of alcohol drinking on gastric precancerous lesions remains unclear. We investigated the relationship of alcohol intake with risk of atrophic gastritis (AG) and intestinal metaplasia (IM). This study included 202,675 Korean adults free from AG and IM on their initial endoscopy who were fo...

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Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2020-12, Vol.29 (12), p.2633-2641
Main Authors: Kim, Kyungeun, Chang, Yoosoo, Ahn, Jiin, Yang, Hyo-Joon, Ryu, Seungho
Format: Article
Language:English
Subjects:
Adult
Alcohol Drinking - adverse effects
Cohort Studies
Female
Humans
Intestinal Neoplasms - etiology
Intestinal Neoplasms - physiopathology
Male
Metaplasia - etiology
Metaplasia - physiopathology
Risk Factors
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Summary:The impact of alcohol drinking on gastric precancerous lesions remains unclear. We investigated the relationship of alcohol intake with risk of atrophic gastritis (AG) and intestinal metaplasia (IM). This study included 202,675 Korean adults free from AG and IM on their initial endoscopy who were followed with repeated endoscopic examinations. A parametric proportional hazards model was used to estimate the adjusted HR (aHR) with 95% confidence interval (CI) for incident AG and IM based on endoscopic diagnosis. During a mean follow-up of 4.7 years, 64,853 incident AG cases and 4,536 IM cases were identified. Alcohol consumption including drinking frequency, quantity, and binge drinking were consistently associated with increased risk of both AG and IM in a dose-response manner. After adjustment for confounders, the multivariable aHRs (95% CIs) for incident IM comparing average alcohol intake of
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-20-0858