Abstract 1167: The GNAS1 T393C polymorphism is a predictor of clinical outcome in esophageal cancer

• Published in: Cancer research (Chicago, Ill.) Ill.), 2010-04, Vol.70 (8_Supplement), p.1167-1167
• Main Authors: Effenberger, Katharina E., Musici, Safije, Yekebas, Emre F., Kutup, Asad, Kamradt, Till, Mina, Sormeh, Kalinin, Viacheslav, Brandt, Burkhard, Pantel, Klaus, Izbicki, Jakob R., Vashist, Yogesh K.
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM10-1167

Background: There is a paucity of prognostic markers in esophageal cancer (EC). Genetic variations determined in the germline DNA of cancer patients may serve as important prognostic factors of clinical outcome since genomic DNA remains unbiased by instability occurring in tumor DNA and is easily accessible in the peripheral blood. G-protein α subunit (Gαs) polymorphism has been identified as a prognostic marker of tumor recurrence and survival in various tumor entities. We genotyped the single nucleotide T393C polymorphism in the GNAS1 gene encoding Gαs, and focused on three different genotypes, TT, TC, and CC. The aim of this study was to evaluate the potential prognostic value of the GNAS1 polymorphism in EC. Methods: Genomic DNA was extracted from peripheral blood leucocytes of 190 patients who underwent complete resection for esophageal cancer and did not receive any neoadjuvant or adjuvant therapy. The GNAS1 genotypes were correlated with clinicopathological parameters, tumor cell dissemination in bone marrow and clinical outcome. Results: The TT and TC genotypes correlated with advanced disease, predominantly characterized by the presence of lymph node metastases (p