Abstract 48: Directing glutamine and glucose metabolism with troglitazone and EGCG limits MCF-7 cell growth

Tumor cell growth requires balanced glutaminolysis and glycolysis which in turn subserve mitochondrial membrane potential (Ψm) and cell growth (DNA synthesis). Troglitazone (TRO) reduces Ψm by 72% (p

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2010-04, Vol.70 (8_Supplement), p.48-48
Main Authors: Friday, R. Ellen, Oliver, Robert, Welbourne, Tomas, Turturro, Francesco
Format: Article
Language:English
Online Access:Get full text
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Summary:Tumor cell growth requires balanced glutaminolysis and glycolysis which in turn subserve mitochondrial membrane potential (Ψm) and cell growth (DNA synthesis). Troglitazone (TRO) reduces Ψm by 72% (p
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM10-48