Abstract 5183: Correlation of cell adhesion molecules expression and prognosis in clinically localized prostate cancer

• Published in: Cancer research (Chicago, Ill.) Ill.), 2010-04, Vol.70 (8_Supplement), p.5183-5183
• Main Authors: Júnior, José Pontes, Ribeiro-Filho, Leopoldo Alves, Reis, Sabrina Thalita, de Oliveira, Luiz Carlos Neves, Dall'Oglio, Marcos, Leite, Kátia R M, Srougi, Miguel
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM10-5183

Introduction and objective: E-cadherin and others adhesion molecules are responsible for the maintenance of the epithelial phenotype. Some studies have reported correlation between alterations in cell adhesion molecules expression and carcinogenesis, but their role in the prostate cancer is not clear. Our aim is to study the expression profiles of E-cadherin and catenins in localized prostate cancer and evaluate their association with recurrence after surgical treatment Methods: For this case-control study, we selected 111 patients with localized tumor submitted to radical prostatectomy. 60 of these patients have not presented recurrence after a median follow-up of 123 months. Recurrence was defined as a PSA level above 0.4ng/ml. E-cadherin and α, β and µ-catenins expression was evaluated by immunohistochemistry in a Tissue Microarray containing two samples from each tumor. We employed a semiquantitative analysis and considered normal when the expression was strong and diffusely positive. We correlated expression with recurrence using the χ2 test and p