Abstract 1343: Protective effect of catechol-O-methyltransferase in human renal cell carcinogenesis

Exposure to carcinogenic catechol estrogens plays a role in the development of kidney cancer. Catechol-O-methyltransferase (COMT) neutralizes the genotoxic effects of these compounds by methoxylation. Although reduced activity of COMT has been suggested as a risk factor for estrogen-associated cance...

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Published in:Cancer research (Chicago, Ill.) Ill.), 2011-04, Vol.71 (8_Supplement), p.1343-1343
Main Authors: Chang, Inik, Liu, Jan, Majid, Shahana, Saini, Sharanjot, Zaman, Mohd S., Chen, Yi, Singh, Kamaldeep, Shahryari, Varahram, Sandhu, Herman, Yamamura, Soichiro, Dahiya, Angela V., Deng, Guoren, Tanaka, Yuichiro
Format: Article
Language:English
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Summary:Exposure to carcinogenic catechol estrogens plays a role in the development of kidney cancer. Catechol-O-methyltransferase (COMT) neutralizes the genotoxic effects of these compounds by methoxylation. Although reduced activity of COMT has been suggested as a risk factor for estrogen-associated cancers, its critical role in kidney cancer and underlying mechanisms of renal cell carcinogenesis are largely unknown. To address the role and function of COMT in renal cell carcinomas (RCC), we initially determined levels of COMT in normal kidney and clear cell RCC. The expression of COMT mRNA was down-regulated in clear cell RCC tissues as determined by quantitative PCR. Low expression of COMT protein in clear cell RCC tissues was also confirmed by immunohistochemical counting of staining score (2.5 vs. 0.5 in normal kidney and clear cell RCC, respectively, p
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2011-1343