Abstract 1861: PPAR γ mediated involucrin induction in aerodigestive preneoplasia in vitro

Effective prevention and monitoring of head and neck malignancy is a critical component of disease control which is significantly underdeveloped. Currently, no validated biomarkers or therapies for human aerodigestive preneoplasia exist. We have increasing interest in PPARγ mediated therapy for oral...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2011-04, Vol.71 (8_Supplement), p.1861-1861
Main Authors: Rosas, Rolando R., Handley, Nathan R., Gaffney, Patrick M., Wuertz, Beverly R., Ondrey, Frank G.
Format: Article
Language:English
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Summary:Effective prevention and monitoring of head and neck malignancy is a critical component of disease control which is significantly underdeveloped. Currently, no validated biomarkers or therapies for human aerodigestive preneoplasia exist. We have increasing interest in PPARγ mediated therapy for oral leukoplakia reversal based on our preliminary clinical trial results. Involucrin expression is associated with squamous differentiation and we hypothesize involucrin would be involved with PPARγ upregulation in differentiation therapies. In our present study we examined the use of involucrin as marker of PPARγ activity in response to treatment and effect of bexarotene on pioglitazone mediated PPARγ activation in oral leukoplakia. In an analysis of an Affymetrix database of human head and neck tumors (41 tumors compared to 13 normal oral mucosa samples), we found involucrin is expressed 5.6fold higher in normal versus tumor samples (P
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2011-1861