Abstract 2257: The survival impact of XPA and XPC genetic polymorphisms on patients with esophageal cancer

Purpose: To investigate the association of the genetic variants in xeroderma pigmentosum groups A (XPA) and C (XPC) with the overall survival duration of the patients with esophageal cancer. Patients and Methods: A total of 531 patients with a diagnosis of esophageal cancer were enrolled in the stud...

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Published in:Cancer research (Chicago, Ill.) Ill.), 2011-04, Vol.71 (8_Supplement), p.2257-2257
Main Authors: Lee, Jang-Ming, Yang, Pei-Wen, Hsieh, Ching-Yueh, Tsai, Pey-Yu, Chen, Chun-Hui, Chen, Jin-Shing, Huang, Pei-Ming, Hsu, Hsao-Hsun, Kuo, Sunn-Wen, Lee, Yung-Chie
Format: Article
Language:English
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Summary:Purpose: To investigate the association of the genetic variants in xeroderma pigmentosum groups A (XPA) and C (XPC) with the overall survival duration of the patients with esophageal cancer. Patients and Methods: A total of 531 patients with a diagnosis of esophageal cancer were enrolled in the study. The genetic variants of XPA in 5’UTR (rs1800975) as well as XPC at exon 15 Lys939Gln (rs2228001) were analyzed with the TaqMan assay from the genomic DNA of peripheral leukocytes. The association of the genotypes and the survival of the patients were analyzed with Cox's multivariate analysis. Results: There was no significant difference of XPA and XPC genotype distribution among patients with various clinical profiles. The overall survival of the patients was significantly influenced by the tumor stage, cell type (squamous cell carcinoma vs. adenocarcinoma) and curative surgical resection (p
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2011-2257