Abstract 5027: Steadily improving survival in lung cancer

• Published in: Cancer research (Chicago, Ill.) Ill.), 2011-04, Vol.71 (8_Supplement), p.5027-5027
• Main Authors: Dillman, Robert O., McClure, Stephanie E., Zusman, Douglas R., VanderMolen, Louis A., Mahdavi, Khosrow, Hafer, Russell A., Cox, Craig A., Joyo, Colin I., Barth, Neil M.
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2011-5027

Background and Purpose: There have been many improvements in the diagnosis and management of lung cancer during the past 25 years, including better imaging and the potential for earlier diagnosis, better surgical staging and introduction of minimally invasive surgery, improved radiation technology, and introduction of several systemic cancer drugs, including targeted therapies, and acceptance of multidisciplinary approaches rather than focusing on single modalities of therapy. We examined how treatment has changed in successive eras and how this relates to survival. Patients and Methods: The Hoag Cancer Institute data base was used to identify patients with lung cancer diagnosed during 1986-2009, who were diagnosed and/or received some or all of their lung cancer treatment at Hoag Hospital within four months of diagnosis. For the four successive 5-year periods, data was summarized for patient demographics and treatment, and observed and relative 5-year survival rates were calculated. Results: Data is summarized in the table below. Conclusion: Over time there have been steady increases in median age, and in the proportion that have adenocarcinoma, are female, have local stage disease, undergo surgery alone as therapy, and receive systemic therapy with surgery as initial treatment. These changes have been associated with a 13.3 percentage point absolute increase in observed survival and an 81% relative increase. Relative 5-year survival increased from 18% to 34%, which contrasts with national data showing an increase from only 14% to 16% in the U.S. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5027. doi:10.1158/1538-7445.AM2011-5027