Abstract 5482: c-Met and DR5 co-expression is an independent prognostic marker for better survival in colorectal carcinoma

Recently, dysregulated over-expression of hepatocyte growth factor (HGF) and its receptor, c-Met has been reported in variety of cancers. However, its role in colo-rectal carcinoma (CRC) has not been fully elucidated. Therefore, we investigated the role of c-Met in a large series of Middle Eastern C...

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Published in:Cancer research (Chicago, Ill.) Ill.), 2011-04, Vol.71 (8_Supplement), p.5482-5482
Main Authors: Uddin, Shahab, Hussain, Azhar R., Ahmed, Maqbool, Al-Sanea, Nasser, AbdulJabbar, Alaa, Ashari, Luai H., Al-Homoud, Samar, Al-Dayel, Fouad, Bavi, Prashant, Al-Kuraya, Khawla S.
Format: Article
Language:English
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Summary:Recently, dysregulated over-expression of hepatocyte growth factor (HGF) and its receptor, c-Met has been reported in variety of cancers. However, its role in colo-rectal carcinoma (CRC) has not been fully elucidated. Therefore, we investigated the role of c-Met in a large series of Middle Eastern CRC patient samples and CRC cell lines. c-Met was over-expressed in 86.8% of CRC and was strongly associated with expression of p-AKT (p
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2011-5482