Abstract 5474: Prediagnostic cytokine levels and the risk of non-Hodgkin lymphoma in a nested case-control study: The Multiethnic Cohort

• Published in: Cancer research (Chicago, Ill.) Ill.), 2012-04, Vol.72 (8_Supplement), p.5474-5474
• Main Authors: Maskarinec, Gertraud, Conroy, Shannon M., Ollberding, Nicholas J., Morimoto, Yukiko, Tom, Elysse S., Franke, Adrian A., Cooney, Robert V., Wilkens, Lynne R., Goodman, Marc T., Hernandez, Brenda Y., Marchand, Loïc Le, Henderson, Brian E., Kolonel, Laurence N.
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2012-5474

Objective: Since immune dysfunction is thought to be the underlying basis for the development of Non-Hodgkin Lymphoma (NHL), obesity and a state of chronic inflammation may increase the risk of the disease. The objective of this analysis was to examine the association of prediagnostic inflammatory marker and adipokine levels in serum with NHL risk. Methods: We conducted a nested case-control analysis (272 cases and 578 controls) within the Multiethnic Cohort Study, which consists of Caucasians, Japanese Americans, Latinos, African Americans, and Native Hawaiians in California and Hawaii. Each case was matched to 2 controls by sex, year of birth, ethnicity, location (HI or CA), date and time of blood draw, and fasting hours before blood draw. A 10-plex panel of cytokines (TNF-α, IFN-γ, GM-CSF, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, and IL-10) was measured in prediagnostic blood samples by Luminex multiplex technology. ELISA assays were used for the adipokines, and CRP was assessed using a Cobas MiraPlus clinical chemistry analyzer. Tertiles of analytes were created and conditional logistic regression was applied to estimate the odds ratios (OR) and 95% confidence intervals (CI), with adjustment for age at blood draw, alcohol, smoking status, and body mass index (BMI). Results: The mean ages at blood draw were 70.0±7.4 and 70.3±7.6 years for cases and controls, respectively. The mean time from blood draw to diagnosis was 3.1±2.3 years with NHL cases comprised of the following lymphoma: 82 diffuse large B-cell, 51 small cell/chronic lymphocytic leukemia, 49 follicular, 15 T-cell, and 75 others. Of all cytokines, IL-10, IL-6, and IL-8 were positively associated with risk for NHL. The respective BMI-adjusted ORsT3v vs T1 were 3.1 (95%CI: 2.0-4.7; ptrend