Abstract 5481: Mitochondrial DNA copy number and lung cancer risk among Chinese female non-smokers

• Published in: Cancer research (Chicago, Ill.) Ill.), 2012-04, Vol.72 (8_Supplement), p.5481-5481
• Main Authors: Mu, Lina, Bonner, Matthew, Irla, Alyssa, Jin, Jiahe, Olson, James, Ellison, Corie, Zhang, Zuo-feng
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2012-5481

Objectives It has been speculated that mitochondrial DNA copy number is involved in carcinogenesis of several cancers. The purpose of this pilot study was to explore the role of mitochondrial DNA copy number in the development of lung cancer among Chinese female non-smoker. Methods A subset of lung cancer cases (N=95) and healthy controls (N=96) were randomly selected from an original lung cancer case-control study conducted in Taiyuan City, China. mtDNA content was determined with Quantitative Real-time Polymerase Chain Reaction (qRT-PCR). Cases and controls were blindly assayed consecutively. Each sample was done in triplicate. Unconditional logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals after adjusting for age, education level and annual personal income. Spearman correlation coefficient was applied to determine correlation between mtDNA copy number and age or indoor air pollution index. Results Lung cancer cases had a significantly lower median mtDNA copy number of 4.5 as opposed to 7.2 in the controls (p