Abstract 1340: Identification of epidermal growth factor receptor (EGFR) polymorphisms that modify risk for squamous cell carcinoma of the head and neck (HNSCC)

• Published in: Cancer research (Chicago, Ill.) Ill.), 2013-04, Vol.73 (8_Supplement), p.1340-1340
• Main Authors: Fung, Christopher, Trent, Kerry, Joyce, Sonali, Zhou, Pei, Nukui, Tomoko, Weeks, Daniel E., Diergaarde, Brenda, Ye, Yuanqing, Wu, Xifeng, Yuan, Jian-Min, Grandis, Jennifer, Weissfeld, Joel L., Romkes, Marjorie, Egloff, Ann Marie
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2013-1340

Background: EGFR is overexpressed in HNSCC and contributes to disease progression. HNSCC arising in individuals with and without tobacco use histories represent distinct disease etiologies. A thorough evaluation of EGFR polymorphisms for association with HNSCC risk has not been reported. Methods: We determined the genotypes at 60 EGFR single nucleotide polymorphisms (SNPs) in 578 white HNSCC patients and 588 white cancer-free controls using the iPLEX gold mass spectrometry-based genotyping assay. EGFR SNPs were selected based on hypothesized function and/or tagging of EGFR with r2 ≥0.8 and minor allele frequencies of ≥5%. Associations with HNSCC risk were tested using the Fisher's exact test for genotype and for trend for number of alleles of each SNP. We also performed these analyses stratified by tobacco use. SNPs significantly associated with HNSCC (p