Abstract 4: Nuclear MTA1 overexpression is associated with aggressive prostate cancer and metastasis in African American men

• Published in: Cancer research (Chicago, Ill.) Ill.), 2013-04, Vol.73 (8_Supplement), p.4-4
• Main Authors: Dias, Steven J., Zhou, Xinchaun, Ivanovic, Marina, Gailey, Michael P., Dhar, Swati, He, Zhi, Penman, Alan, Levenson, Anait S.
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2013-4

Metastasis-associate protein 1 (MTA1) plays essential role in prostate cancer (PCa) progression and metastasis. We hypothesized that nuclear MTA1 overexpression in primary tumor tissues may provide meaningful information on prediction of poor prognosis, i.e. MTA1 may serve as a prognostic biomarker for aggressive PCa and a predictor of recurrent disease and metastasis. We used tissue microarrays and clinicopathological information of 301 patients (146 Caucasian Americans and 155 African Americans) who underwent prostatectomy in University of Mississippi Medical Center, Jackson, MS and in University of Iowa, Iowa City, IA. We evaluated MTA1 expression by immunohistochemistry with the emphasis on subcellular localization and total staining score, which accounted intensity and frequency. MTA1 was detected in both cytoplasm and nucleus, however exhibited different expression patterns in terms of subcellular localization depending on pathological category of PCa and metastasis. A significant statistical correlation (p=0.063) was observed between MTA1 nuclear staining and localized PCa compared to PIN, reaching more significance with the worst grade (Gleason >7) and metastatic lesions (p