Abstract 4358: MicroRNA-198 inhibits non-small cell lung cancer migration and invasion through targeting OTX1 and VCP

• Published in: Cancer research (Chicago, Ill.) Ill.), 2014-10, Vol.74 (19_Supplement), p.4358-4358
• Main Authors: Kim, Jin-Ah, Yang, Junguk, Jo, Yeong Nang, Lee, Chang Woo, Lee, Ok-Jun, Choi, Song-Yi, Kang, Jong Soon, Yun, Jieun
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2014-4358

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. In previous studies, microRNA-198 (miR-198) was shown to be significantly downregulated in lung adenocarcinoma-associated malignant pleural effusion and suggested as a diagnostic biomarker. Herein, we show that miR-198 regulates migration and invasion of NSCLS cells by directly targeting orthodenticle homeobox 1 (OTX1) and valosin containing protein (VCP). Expression of miR-198 suppressed migration and invasion of NSCLS cells, whereas inhibition of miR-198 expression increased the invasive efficiency of the cancer cells. MiR-198 directly targets 3′UTR of OTX1 and VCP, thus regulates their protein level. Furthermore, we found reduced levels of miR-198 in human NSCLS tissue samples compared to adjacent normal tissues. Our findings indicate that miR-198 regulates NSCLC cell migration and invasion, partially via the down-regulation of OTX1 and VCP. Thus, miR-198 may represent a potential therapeutic target for NSCLC intervention. Citation Format: Jin-Ah Kim, Junguk Yang, Yeong Nang Jo, Chang Woo Lee, Ok-Jun Lee, Song-Yi Choi, Jong Soon Kang, Jieun Yun. MicroRNA-198 inhibits non-small cell lung cancer migration and invasion through targeting OTX1 and VCP. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4358. doi:10.1158/1538-7445.AM2014-4358