Abstract LB-123: Novel function of STAT1 pathway as a modulator of tumor progression in serous papillary endometrial cancer

• Published in: Cancer research (Chicago, Ill.) Ill.), 2014-10, Vol.74 (19_Supplement), p.LB-123-LB-123
• Main Authors: Kharma, Budiman, Baba, Tsukasa, Matsumura, Noriomi, Kang, Hyun Sook, Murakami, Ryusuke, Yamaguchi, Ken, Hamanishi, Junzo, Mandai, Masaki, Murphy, Susan K, Konishi, Ikuo
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2014-LB-123

Serous papillary endometrial cancers (SPEC) are highly progressive with poor prognosis, and its oncogenic profile is known different from endometrioid endometrial cancers. It, however, still remains unclear that which pathway promotes tumor progression. The IFN-γ transcription factor signal transducer and activator of transcription 1 (STAT1) has been considered as a tumor suppressor with transcription-dependent and transcription-independent mechanisms, but recent studies showed STAT1 was associated with poor prognosis in some cancers with unclear mechanisms. In this study, we performed a genome-wide analysis by microarray analysis of 63 human endometrial cancers which revealed STAT1 pathway was constitutively up-regulated in SPEC, and its expression was confirmed significantly higher in SPECs tissue cancer by immunohistochemical staining (p