Abstract 2458: Targeting membrane fluidity as a therapeutic strategy in cancer using BPM 31510

Cancer cells membranes are relatively more fluid compared to healthy cells. Higher fluidity in cancer cells closely relate to their invasive potential, proliferation, and metastatic ability. Pharmacological modulation of membrane fluidity as a novel therapeutic strategy for potential treatment of ca...

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Published in:Cancer research (Chicago, Ill.) Ill.), 2015-08, Vol.75 (15_Supplement), p.2458-2458
Main Authors: Garg, Sumit, Dhavala, Sirisha, Krumova, Katerina, Vishnudas, Vivek K., Jimenez, Joaquin J., Kiebish, Michael, Sarangarajan, Rangaprasad, Narain, Niven R.
Format: Article
Language:English
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Summary:Cancer cells membranes are relatively more fluid compared to healthy cells. Higher fluidity in cancer cells closely relate to their invasive potential, proliferation, and metastatic ability. Pharmacological modulation of membrane fluidity as a novel therapeutic strategy for potential treatment of cancer is investigated in this study. BPM 31510, a proprietary CoQ10 based liposomal formulation currently in clinical trials affects cell membrane fluidity to influence cancer cell survival. To study the effect of BPM 31510 on biophysical parameters of membrane structure in cancer cells, the CoQ10 concentration in the liposomes was systematically increased and the membrane rigidity (Fluorescence Anisotropy) as function of temperature was measured. A progressive (significant, p
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2015-2458