Abstract 837: PSMB8 as a candidate marker of responsiveness to preoperative radiotherapy in rectal cancer patients

Prediction of individual responsiveness is urgently needed, specifically in locally advanced rectal cancer (LARC) patients who underwent preoperative chemoradiotherapy (CRT). The present study, RNA-Seq was used to compare the basal expression profile between responders and non-responders to preopera...

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Published in:Cancer research (Chicago, Ill.) Ill.), 2017-07, Vol.77 (13_Supplement), p.837-837
Main Authors: Ha, Yejin, Tak, Ka hee, Kim, Chan wook, Roh, Seon Ae, Choi, Eun Kyung, Cho, Dong Hyung, Kim, Jeong-Hwan, Kim, Seon-Kyu, Kim, Seon-Young, Kim, Yong Sung, Kim, Jin-Cheon
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Language:English
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Summary:Prediction of individual responsiveness is urgently needed, specifically in locally advanced rectal cancer (LARC) patients who underwent preoperative chemoradiotherapy (CRT). The present study, RNA-Seq was used to compare the basal expression profile between responders and non-responders to preoperative CRT, in correlation with the tumor regression grade (TRG) among 22 LARC patients. Eight differentially expressed genes (B3GALT4, HSPA1B, KRBOX1, PPBP, PPP1R18, PSMB8, SLC39A7, and TAP2) associated with preoperative CRT responses were primarily identified among the 22 LARC patients by RNA-Seq (p16-fold difference). Among these genes, PSMB8 and SLC39A7 were upregulated in the responsive group in the other 40 LARC patients (p
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2017-837