Abstract 2333: Genetic characterization of programmed cell death in aneuploid yeast cells

• Published in: Cancer research (Chicago, Ill.) Ill.), 2018-07, Vol.78 (13_Supplement), p.2333-2333
• Main Authors: Onyundo, Megan, Sanborn, Matthew, Timmel, Victoria, Austriaco, Nicanor
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2018-2333

Aneuploidy is the genetic state of a cell that has a chromosomal number that is not an exact multiple of the haploid complement. It is a leading cause of spontaneous abortions and of mental retardation in humans, and is a characteristic defect in cancer. Yeast cells that are aneuploid manifest a diversity of phenotypes including cell cycle defects, genomic instability, protein imbalance, chaperone stress and proteotoxicity. We are investigating the links between aneuploidy on the budding yeast, Saccharomyces cerevisiae and programmed cell death. We have shown that aneuploid yeast cells are more sensitive to ethanol-induced cell death. In addition, we have also shown that caloric restriction protects aneuploid yeast from program cell death. [In addition to funding from the RI-INBRE Program, our laboratory is supported by grant NIGMS R15 GM110578, awarded to N. Austriaco.] Citation Format: Megan Onyundo, Matthew Sanborn, Victoria Timmel, Nicanor Austriaco. Genetic characterization of programmed cell death in aneuploid yeast cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2333.