Abstract B59: Predictors of early versus late biochemical recurrence after open radical prostatectomy in a patient cohort with T2/T3N0M0 prostate cancer treated within the PSA-era

• Published in: Cancer research (Chicago, Ill.) Ill.), 2012-02, Vol.72 (4_Supplement), p.B59-B59
• Main Authors: Shahabi, Ahva, Gill, Inderbir S., Lieskovsky, Gary, Skinner, Eila C., Daneshmand, Siamak, Pinski, Jacek, Stern, Mariana C.
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.PRCA2012-B59

Introduction: Patients treated with radical prostatectomy (RP) differ in their risk of prostate cancer (PCa) recurrence. By determining factors associated with an increased risk of biochemical (PSA) recurrence (BCR), patients can be provided with personalized care to prevent disease progression. Identifying which patients are at risk of earlier versus later BCR after surgery is of interest in order to guide monitoring of disease progression and treatment options. Objectives: We evaluated variables associated with PCa progression among a patient population treated with RP. In particular, we examined factors associated with earlier BCR (≤5 years post-RP) versus later BCR (>5 years post-RP) taking into account potential differences across racial/ethnic groups present in this population. Methods: An IRB approved database was used to obtain data on a patient population at USC/Norris Comprehensive Cancer Center with pathologically confirmed localized PCa (T2/T3) without lymph node involvement who underwent RP in the PSA era (1988-2009). We analyzed data on 2,485 patients after excluding individuals treated with neo-adjuvant hormonal therapy. Kaplan Meier and Cox regression analyses were used to evaluate biochemical recurrence-free survival (BCRFS) and risk of BCR adjusting for clinical variables. Results: Among the 2,485 patients, 268 (11%) experienced BCR. Of these individuals, 212 (79%) had BCR ≤5 years after RP versus 56 (21%) >5 years after surgery. The median (range) of follow-up time among patients without any recurrence is 7.45 (2.0-20.4) years and among patients with BCR is 2.9(0.17-15.12) years. The racial distribution is 2,163 (87%) Non-Hispanic White (NHW), 126 (5%) Hispanic, 95 (4%) African-American, and 78 (3%) Asian/Pacific Islander, with 23 patients excluded due to unknown race. Compared to other racial/ethnic groups, more African-American men were diagnosed when younger than 65 years old (66%) (p