Mood Changes following Acute Tryptophan Depletion in Healthy Adults

A decrease in central serotonergic activity following plasma tryptophan depletion has been shown to provoke a deterioration of mood. We studied the impact of sex and aggressive traits on mood changes following tryptophan depletion in healthy volunteers. Twelve healthy subjects (6 males, 6 females, 2...

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Bibliographic Details
Published in:Psychopathology 2002-07, Vol.35 (4), p.234-240
Main Authors: Schmeck, Klaus, Sadigorsky, Shella, Englert, Ekkehart, Demisch, Lothar, Dierks, Thomas, Barta, Stefan, Poustka, Fritz
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Affect - physiology
Aggression
Biological and medical sciences
Depression
Depression - psychology
Emotions
Female
Humans
Male
Medical sciences
Mood disorders
Original Paper
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Sex Factors
Sexual Behavior
Tryptophan - deficiency
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Summary:A decrease in central serotonergic activity following plasma tryptophan depletion has been shown to provoke a deterioration of mood. We studied the impact of sex and aggressive traits on mood changes following tryptophan depletion in healthy volunteers. Twelve healthy subjects (6 males, 6 females, 24–31 years), who were screened for psychiatric and non-psychiatric medical illness, were administered a tryptophan-depleting amino acid mixture (TD) and a placebo mixture on two different occasions in a double-blind crossover design. Psychometric measures included the preliminary determination of aggressive traits and depression and repeated assessments of mood and emotionality. The tryptophan-free amino acid mixture caused a marked depletion of plasma tryptophan with lowest levels occurring between 3 and 5 h after TD. Maximum changes in mood occurred about 10 h after TD, but only in high-aggressive women who scored significantly higher in arousal, anger and depressed mood, whereas low-aggressive women and men did not show any effect of TD. In addition, we could not confirm an increase in aggressive mood (anger) after TD in males with higher scores of trait aggression, presumably because the level of trait aggression was not high enough in this group. Due to the small sample size, our results that tryptophan depletion exerts a rapid mood-lowering effect on healthy women with pre-existing aggressive traits can only be seen as preliminary and have to be confirmed in further studies with larger samples.
ISSN:0254-4962
1423-033X
DOI:10.1159/000063827