Substance-P-Mediated Intestinal Inflammation: Inhibitory Effects of CP 96,345 and SMS 201-995

The proinflammatory peptide substance P (SP) has been shown to be intimately involved in the local inflammatory processes ofTrichinella-spiralis-induced murine intestinal inflammation. Significant increases in SP, increased myeloperoxidase levels coupled with local morphological deterioration of the...

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Bibliographic Details
Published in:Neuroimmunomodulation 1994-11, Vol.1 (6), p.350-356
Main Authors: Kataeva, Galina, Agro, Albert, Stanisz, Andrzej M.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biomarkers
Biphenyl Compounds - pharmacology
Biphenyl Compounds - therapeutic use
Female
Inflammation
Intestinal Diseases, Parasitic - drug therapy
Intestinal Diseases, Parasitic - physiopathology
Jejunum - drug effects
Jejunum - pathology
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Neurokinin-1 Receptor Antagonists
Neutrophils - enzymology
Octreotide - pharmacology
Octreotide - therapeutic use
Original Paper
Peroxidase - analysis
Receptors, Neurokinin-1 - physiology
Substance P - antagonists & inhibitors
Substance P - biosynthesis
Substance P - physiology
Trichinella spiralis
Trichinellosis - drug therapy
Trichinellosis - physiopathology
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Description
Summary:The proinflammatory peptide substance P (SP) has been shown to be intimately involved in the local inflammatory processes ofTrichinella-spiralis-induced murine intestinal inflammation. Significant increases in SP, increased myeloperoxidase levels coupled with local morphological deterioration of the jejunum and impaired lymphocyte responses to exogenous SP in vitro have been associated with the model. We have recently determined that the elimination of increased levels of SP via anti-SP antibody therapy can spare the murine gastrointestinal tract much of the pathologies associated with the parasitic infection. Here we further demonstrate that the somatostatin analogue SMS 201 -995 as well as the SP receptor antagonist CP 96,345 can effectively decrease the inflammation and lost lymphocyte function seen in the jejunum ofT. spiralis-infected mice. Again, both intestinal morphology and myeloperoxidase levels were shown to return to normal values upon treatment. The above results suggest that SP is an important modulator of gastrointestinal inflammation.
ISSN:1021-7401
1423-0216
DOI:10.1159/000097187