Modifications of abdominal fat and hepatic insulin clearance during severe caloric restriction

Using computed tomography on 19 obese female subjects, we determined abdominal adipose tissue, both subcutaneous and visceral adipose tissue, before and after 2 weeks of a very low caloric diet (VLCD). The following parameters were also determined before and after 15-20 days of VLCD: plasma glucose...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 1990, Vol.34 (6), p.359-365
Main Authors: Bosello, O, Zamboni, M, Armellini, F, Zocca, I, Bergamo Andreis, I.A, Smacchia, C, Milani, M.P, Cominacini, L
Format: Article
Language:English
Subjects:
Abdomen
abdominal fat
Adipose Tissue - metabolism
Adolescent
Adult
Biological and medical sciences
blood glucose
Blood Glucose - analysis
body mass index
Body Weight
c-peptide
C-Peptide - analysis
Diet, Reducing
Female
Humans
insulin
Insulin - blood
Insulin - metabolism
lean body mass
Liver - metabolism
low calorie diet
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Original Paper
Original Papers
tomography
very low calorie diet
women
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Summary:Using computed tomography on 19 obese female subjects, we determined abdominal adipose tissue, both subcutaneous and visceral adipose tissue, before and after 2 weeks of a very low caloric diet (VLCD). The following parameters were also determined before and after 15-20 days of VLCD: plasma glucose and insulin levels, oral glucose tolerance test, basal pancreatic insulin secretion estimated by fasting C peptide (Cp), and fasting insulin hepatic clearance calculated by Cp/insulin molar ratio. After VLCD the body weight and body mass index significantly declined (p < 0.01); whereas abdominal adipose tissue and visceral abdominal tissue (VAT) significantly decreased (p < 0.01), modifications of subcutaneus abdominal tissue (SAT) were not significant. Fasting insulin levels and plasma glucose response to oral glucose load significantly decreased (p < 0.05). Insulin response remained unchanged. Cp immunoreactive insulin (IRI) significantly increased (p < 0.01). A significant positive correlation was found between delta VAT and delta Cp/IRI before and after VLCD (p < 0.01). Our data seem to suggest that the weight loss induced by VLCD fundamentally involves a decrease in VAT. The reduction in visceral fat could be associated with an increase in hepatic insulin clearance.
ISSN:0250-6807
1421-9697
DOI:10.1159/000177610