Association of Bone Mineral Density with Albuminuria and Estimated Glomerular Filtration Rate : The Dong-gu Study

Background: Kidney dysfunction and albuminuria may be associated with BMD. However, little evidence has been reported on relationships between BMD and eGFR and albuminuria. Methods: A total of 8,992 subjects aged 50 years or older participated in a survey conducted. Participants had their lumbar spi...

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Bibliographic Details
Published in:Kidney & blood pressure research 2013-01, Vol.37 (2-3), p.132-141
Main Authors: Choi, Seong-Woo, Kim, Hye-Yeon, Ahn, Hye-Ran, Lee, Young-Hoon, Kweon, Sun-Seog, Choi, Jin-Su, Rhee, Jung-Ae, Nam, Hae-Sung, Jeong, Seul-Ki, Park, Kyeong-Soo, Ryu, So-Yeon, Song, Hye-Rim, Shin, Min-Ho
Format: Article
Language:English
Subjects:
Aged
Albuminuria
Albuminuria - pathology
Albuminuria - physiopathology
Bone Density - physiology
Bone mineral denstiy
Creatinine - blood
Estimated glomerular filtration rate
Female
Femur Neck - pathology
Glomerular Filtration Rate - physiology
Humans
Kidney Function Tests
Lumbar Vertebrae - pathology
Male
Middle Aged
Original Paper
Prospective Studies
Republic of Korea
Sex Characteristics
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Summary:Background: Kidney dysfunction and albuminuria may be associated with BMD. However, little evidence has been reported on relationships between BMD and eGFR and albuminuria. Methods: A total of 8,992 subjects aged 50 years or older participated in a survey conducted. Participants had their lumbar spine and femoral neck BMD measured by a Lunar Prodigy bone densitometer (GE, Madison, WI). Kidney function was assessed using MDRD eGFR and diagnosis of albuminuria was based on albumin-creatinine ratio. Results: ACR was negatively associated with lumbar spine and femur neck BMD in females (lumbar spine: 1.001, 0.988, 0.974 and 0.979 g/cm 2 , p < 0.001; femur neck: 0.796, 0.790, 0.783 and 0.782 g/cm 2 , p = 0.002), but not in males, after adjusting for covariates. Additionally, eGFR was shown to be negatively associated with lumbar spine BMD after adjusting for covariates (male: 1.181, 1.166, 1.152 and 1.149 g/cm 2 , p = 0.001; female: 0.997, 0.980, 0.979 and 0.982 g/cm 2 , p = 0.005), but demonstrated no association with femur BMD. Conclusions: ACR in females was negatively associated with lumbar spine and femur neck BMD, but not in males. eGFR was negatively associated with lumbar spine BMD in both males and females.
ISSN:1420-4096
1423-0143
DOI:10.1159/000350067