Red Blood Cell Alloimmunization in Sickle Cell Disease: Listen to Your Ancestors

Red blood cell (RBC) alloimmunization occurs in approximately 30% of transfused sickle cell disease patients compared to 2-5% of all transfusion recipients. Because RBC transfusion is an important part of therapy in sickle cell disease, the need for additional antigen matching once alloimmunization...

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Bibliographic Details
Published in:Transfusion medicine and hemotherapy 2014-11, Vol.41 (6), p.431-435
Main Authors: Campbell-Lee, Sally A., Kittles, Rick A.
Format: Article
Language:English
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Summary:Red blood cell (RBC) alloimmunization occurs in approximately 30% of transfused sickle cell disease patients compared to 2-5% of all transfusion recipients. Because RBC transfusion is an important part of therapy in sickle cell disease, the need for additional antigen matching once alloimmunization occurs is problematic and leads to therapeutic limitations. Thus, identification of risk factors would benefit this patient population. Genome-wide analyses, in particular, methods which take into account genetic ancestry such as admixture mapping, could identify molecular markers which could be used to identify immune responders to transfusion.
ISSN:1660-3796
1660-3818
DOI:10.1159/000369513