Red Blood Cell Alloimmunization in Sickle Cell Disease: Listen to Your Ancestors

Red blood cell (RBC) alloimmunization occurs in approximately 30% of transfused sickle cell disease patients compared to 2-5% of all transfusion recipients. Because RBC transfusion is an important part of therapy in sickle cell disease, the need for additional antigen matching once alloimmunization...

Full description

Saved in:
Bibliographic Details
Published in:Transfusion medicine and hemotherapy 2014-11, Vol.41 (6), p.431-435
Main Authors: Campbell-Lee, Sally A., Kittles, Rick A.
Format: Article
Language:English
Subjects:
Review
Review Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c424t-2437d5b7571c48416fe0a89a386a32bc9e4cc3b84538d29b2f42fe64868adfb3
cites cdi_FETCH-LOGICAL-c424t-2437d5b7571c48416fe0a89a386a32bc9e4cc3b84538d29b2f42fe64868adfb3
container_end_page 435
container_issue 6
container_start_page 431
container_title Transfusion medicine and hemotherapy
container_volume 41
creator Campbell-Lee, Sally A.
Kittles, Rick A.
description Red blood cell (RBC) alloimmunization occurs in approximately 30% of transfused sickle cell disease patients compared to 2-5% of all transfusion recipients. Because RBC transfusion is an important part of therapy in sickle cell disease, the need for additional antigen matching once alloimmunization occurs is problematic and leads to therapeutic limitations. Thus, identification of risk factors would benefit this patient population. Genome-wide analyses, in particular, methods which take into account genetic ancestry such as admixture mapping, could identify molecular markers which could be used to identify immune responders to transfusion.
doi_str_mv 10.1159/000369513
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1159_000369513</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1654702050</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-2437d5b7571c48416fe0a89a386a32bc9e4cc3b84538d29b2f42fe64868adfb3</originalsourceid><addsrcrecordid>eNptkUtLxDAUhYMojq-Fe5GAG12M5tU0dSGM42OEEUVn4yqkaTrGaZsxaQX99VaqRcHVvXC-e-4LgF2MjjGOkhOEEOVJhOkK2MCcoyEVWKz-5HHCB2AzhBeECBOUrIMBiXiMEoo2wP2DyeB54VwGx6Yo4KgonC3LprIfqraugraCj1YvCtPpFzYYFcwpnNpQmwrWDj65xsNRpU2onQ_bYC1XRTA733ELzK4uZ-PJcHp3fTMeTYeaEVYPCaNxFqVxFGPNBMM8N0iJRFHBFSWpTgzTmqaCRVRkJElJzkhuOBNcqCxP6RY462yXTVqaTJuq9qqQS29L5d-lU1b-VSr7LOfuTTIiEGNJa3D4beDda9POLksbdLuiqoxrgsQ8YjEiKEItetSh2rsQvMn7NhjJrwfI_gEtu_97rp78uXgL7HXAQvm58T3Q1x_8K89uJx0hl1lOPwEbe5VQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1654702050</pqid></control><display><type>article</type><title>Red Blood Cell Alloimmunization in Sickle Cell Disease: Listen to Your Ancestors</title><source>PubMed Central（OA）</source><creator>Campbell-Lee, Sally A. ; Kittles, Rick A.</creator><creatorcontrib>Campbell-Lee, Sally A. ; Kittles, Rick A.</creatorcontrib><description>Red blood cell (RBC) alloimmunization occurs in approximately 30% of transfused sickle cell disease patients compared to 2-5% of all transfusion recipients. Because RBC transfusion is an important part of therapy in sickle cell disease, the need for additional antigen matching once alloimmunization occurs is problematic and leads to therapeutic limitations. Thus, identification of risk factors would benefit this patient population. Genome-wide analyses, in particular, methods which take into account genetic ancestry such as admixture mapping, could identify molecular markers which could be used to identify immune responders to transfusion.</description><identifier>ISSN: 1660-3796</identifier><identifier>EISSN: 1660-3818</identifier><identifier>DOI: 10.1159/000369513</identifier><identifier>PMID: 25670930</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger GmbH</publisher><subject>Review ; Review Article</subject><ispartof>Transfusion medicine and hemotherapy, 2014-11, Vol.41 (6), p.431-435</ispartof><rights>2014 S. Karger GmbH, Freiburg</rights><rights>Copyright © 2014 by S. Karger GmbH, Freiburg 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-2437d5b7571c48416fe0a89a386a32bc9e4cc3b84538d29b2f42fe64868adfb3</citedby><cites>FETCH-LOGICAL-c424t-2437d5b7571c48416fe0a89a386a32bc9e4cc3b84538d29b2f42fe64868adfb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280449/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280449/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25670930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campbell-Lee, Sally A.</creatorcontrib><creatorcontrib>Kittles, Rick A.</creatorcontrib><title>Red Blood Cell Alloimmunization in Sickle Cell Disease: Listen to Your Ancestors</title><title>Transfusion medicine and hemotherapy</title><addtitle>Transfus Med Hemother</addtitle><description>Red blood cell (RBC) alloimmunization occurs in approximately 30% of transfused sickle cell disease patients compared to 2-5% of all transfusion recipients. Because RBC transfusion is an important part of therapy in sickle cell disease, the need for additional antigen matching once alloimmunization occurs is problematic and leads to therapeutic limitations. Thus, identification of risk factors would benefit this patient population. Genome-wide analyses, in particular, methods which take into account genetic ancestry such as admixture mapping, could identify molecular markers which could be used to identify immune responders to transfusion.</description><subject>Review</subject><subject>Review Article</subject><issn>1660-3796</issn><issn>1660-3818</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNptkUtLxDAUhYMojq-Fe5GAG12M5tU0dSGM42OEEUVn4yqkaTrGaZsxaQX99VaqRcHVvXC-e-4LgF2MjjGOkhOEEOVJhOkK2MCcoyEVWKz-5HHCB2AzhBeECBOUrIMBiXiMEoo2wP2DyeB54VwGx6Yo4KgonC3LprIfqraugraCj1YvCtPpFzYYFcwpnNpQmwrWDj65xsNRpU2onQ_bYC1XRTA733ELzK4uZ-PJcHp3fTMeTYeaEVYPCaNxFqVxFGPNBMM8N0iJRFHBFSWpTgzTmqaCRVRkJElJzkhuOBNcqCxP6RY462yXTVqaTJuq9qqQS29L5d-lU1b-VSr7LOfuTTIiEGNJa3D4beDda9POLksbdLuiqoxrgsQ8YjEiKEItetSh2rsQvMn7NhjJrwfI_gEtu_97rp78uXgL7HXAQvm58T3Q1x_8K89uJx0hl1lOPwEbe5VQ</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Campbell-Lee, Sally A.</creator><creator>Kittles, Rick A.</creator><general>S. Karger GmbH</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141101</creationdate><title>Red Blood Cell Alloimmunization in Sickle Cell Disease: Listen to Your Ancestors</title><author>Campbell-Lee, Sally A. ; Kittles, Rick A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-2437d5b7571c48416fe0a89a386a32bc9e4cc3b84538d29b2f42fe64868adfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Review</topic><topic>Review Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campbell-Lee, Sally A.</creatorcontrib><creatorcontrib>Kittles, Rick A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transfusion medicine and hemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campbell-Lee, Sally A.</au><au>Kittles, Rick A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red Blood Cell Alloimmunization in Sickle Cell Disease: Listen to Your Ancestors</atitle><jtitle>Transfusion medicine and hemotherapy</jtitle><addtitle>Transfus Med Hemother</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>41</volume><issue>6</issue><spage>431</spage><epage>435</epage><pages>431-435</pages><issn>1660-3796</issn><eissn>1660-3818</eissn><abstract>Red blood cell (RBC) alloimmunization occurs in approximately 30% of transfused sickle cell disease patients compared to 2-5% of all transfusion recipients. Because RBC transfusion is an important part of therapy in sickle cell disease, the need for additional antigen matching once alloimmunization occurs is problematic and leads to therapeutic limitations. Thus, identification of risk factors would benefit this patient population. Genome-wide analyses, in particular, methods which take into account genetic ancestry such as admixture mapping, could identify molecular markers which could be used to identify immune responders to transfusion.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger GmbH</pub><pmid>25670930</pmid><doi>10.1159/000369513</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1660-3796
ispartof Transfusion medicine and hemotherapy, 2014-11, Vol.41 (6), p.431-435
issn 1660-3796
1660-3818
language eng
recordid cdi_crossref_primary_10_1159_000369513
source PubMed Central（OA）
subjects Review
Review Article
title Red Blood Cell Alloimmunization in Sickle Cell Disease: Listen to Your Ancestors
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T23%3A56%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Red%20Blood%20Cell%20Alloimmunization%20in%20Sickle%20Cell%20Disease:%20Listen%20to%20Your%20Ancestors&rft.jtitle=Transfusion%20medicine%20and%20hemotherapy&rft.au=Campbell-Lee,%20Sally%20A.&rft.date=2014-11-01&rft.volume=41&rft.issue=6&rft.spage=431&rft.epage=435&rft.pages=431-435&rft.issn=1660-3796&rft.eissn=1660-3818&rft_id=info:doi/10.1159/000369513&rft_dat=%3Cproquest_cross%3E1654702050%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c424t-2437d5b7571c48416fe0a89a386a32bc9e4cc3b84538d29b2f42fe64868adfb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1654702050&rft_id=info:pmid/25670930&rfr_iscdi=true