A Case Report of Triple-Positive Micropapillary Carcinoma of the Male Breast

• Published in: Breast care (Basel, Switzerland) Switzerland), 2018-07, Vol.13 (3), p.192-194
• Main Authors: Shuja, Jamila, Ahmad, Iftikhar, Arshad, Sidra, Manzoor, Hina, Kakar, Shahwali, Ahmad, Khushnaseeb
• Format: Article
• Language: English
• Subjects: Novel Insights from Clinical Practice
• ISSN: 1661-3791; 1661-3805
• DOI: 10.1159/000486665

Background: Micropapillary carcinoma (MPC), a morphologically distinct subtype of invasive ductal carcinoma, of the male breast is an exceedingly uncommon disease. Case Report: Herein, we report a case of triple-positive MPC of the male breast with axillary lymph node involvement and no recurrence for over 2 years. Specifically, a 60-year-old male patient presented with a hard, elastic, and well-defined painless mass in the right breast. The patient underwent unilateral (right) modified radical mastectomy with axillary clearance. Histopathology revealed MPC grade 3 and metastasis in 16/16 lymph nodes. Hormone receptor analysis demonstrated strong positivity (total score 08) for estrogen/progesterone receptors and overexpression (score 3+) of human epidermal growth factor receptor 2. The patient received adjuvant chemotherapy (6 courses of CAF: cyclophosphamide, doxorubicin, and 5-fluorouracil), radiation, and tamoxifen. The patient has remained disease-free for over 2 years. Conclusion: This study demonstrates that triple-positive MPC of the male breast as a rare malignancy appears to respond promisingly to multimodality treatment.