Breast Cancer Metastasis in the Skin with Hyperkeratotic Pigmentation Caused by Melanocyte Colonization

Pigmented breast cancer in the skin caused by nonneoplastic melanocytes of epidermal origin is a rare condition of metastasis from breast cancer, but the pathogenesis of this phenomenon is almost unknown. In this report, we describe a case of breast cancer metastasis in the skin with prominent hyper...

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Bibliographic Details
Published in:Case reports in oncology 2018-10, Vol.11 (3), p.660-664
Main Authors: Ishihara-Yusa, Shino, Fujimura, Taku, Lyu, Chunbing, Sugawara, Masayuki, Sakamoto, Kazuhiro, Aiba, Setsuya
Format: Article
Language:English
Subjects:
Breast cancer
Case Report
Case reports
Cytokines
Hyperkeratosis
IL-17
IL-23
Mastectomy
Melanocyte colonization
Metastasis
Pathogenesis
Psoriasis
Roles
Tumorigenesis
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Summary:Pigmented breast cancer in the skin caused by nonneoplastic melanocytes of epidermal origin is a rare condition of metastasis from breast cancer, but the pathogenesis of this phenomenon is almost unknown. In this report, we describe a case of breast cancer metastasis in the skin with prominent hyperkeratotic pigmentation caused by nonneoplastic melanocyte colonization. Immunohistochemical staining revealed that the metastatic tumor cells produced IL-23, which is reported not only to induce IL-17 but also to inhibit cell apoptosis in breast cancer cells, which affects tumor progression. In addition to IL-23, substantial numbers of IL-17-producing cells were detected at the peritumoral area, suggesting that IL-17 might induce not only melanogenesis but also keratinocyte proliferation and tumorigenesis. Our report suggests possible mechanisms of hyperkeratotic pigmentation of breast cancer metastasis in the skin.
ISSN:1662-6575
1662-6575
DOI:10.1159/000493186