Catalase (antioxidant enzyme) activity in streptozotocin-induced diabetic rats

Background: High concentration and/or inadequate removal of reactive oxygen species may result in oxidative stress that may cause severe metabolic malfunction. An imbalance in antioxidant enzymes has been related to specific pathologies such as diabetic complications. Catalase catalyzes the reductio...

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Published in:Dubai diabetes and endocrinology journal 2019-03, Vol.15 (1), p.22-24
Main Authors: Qujeq, Durdi, Rezvani, Timur
Format: Article
Language:English
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Summary:Background: High concentration and/or inadequate removal of reactive oxygen species may result in oxidative stress that may cause severe metabolic malfunction. An imbalance in antioxidant enzymes has been related to specific pathologies such as diabetic complications. Catalase catalyzes the reduction of hydroperoxides, thereby protecting mammalian cells against oxidative damage. In addition, catalase is active in neutralizing reactive oxygen species and so removes cellular superoxide and peroxides before they react with metal catalysts to form more reactive species. We investigated the status of catalase activity in erythrocytes of streptozotocin (STZ)-induced diabetic rats. Method: Catalase activity was measured by using spectrophtometric techniques. Result: Catalase activity increased in diabetic rats compared to control group [25.7 ± 2.8 vs. 16.3 ± 2.1 mmol H2O2 per min/ mg of protein, mean ± SD, p < 0.05]. Our results show that catalase activity increased significantly in the erythrocytes of STZ-induced diabetic rats. (Int J Diabetes Metab 15: 22-24, 2007)
ISSN:2673-1797
1606-7754
2673-1738
2073-5944
DOI:10.1159/000497630