Efficacy and Tolerability of Topical Polyphenon E in Multiple “Seborrheic Keratosis-Like” Lesions of the Groin in an Immunocompetent 26-Year-Old Man

Polyphenon E 10%, a green tea extract containing epigallocatechin gallate (EGCG) as the main active compound, is a topical formulation indicated for the treatment of genital warts. Polyphenon E has also shown to be very effective in the treatment of periungual and plane warts. Here, we report a dram...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in dermatology 2019-09, Vol.11 (3), p.310-316
Main Authors: Pizzini, Luigi, De Luca, Graziano, Milani, Massimo
Format: Article
Language:English
Subjects:
Antiviral drugs
Apoptosis
Biopsy
bowenoid papulosis
case report
Case reports
Epidermal growth factor
genital warts
green tea extract
Human papillomavirus
Mens health
seborrheic keratosis
Single Case
Skin
Skin diseases
Tea
Warts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polyphenon E 10%, a green tea extract containing epigallocatechin gallate (EGCG) as the main active compound, is a topical formulation indicated for the treatment of genital warts. Polyphenon E has also shown to be very effective in the treatment of periungual and plane warts. Here, we report a dramatic clinical effect of topical treatment with polyphenon E in a subject with multiple “seborrheic keratosis-like” lesions of the genital area. An immunocompetent 26-year-old Caucasian man came to our attention in October 2018. The subject, a regular blood donor, presented several (more than 100) light brown dome-shaped papular lesions in the groin area and in the penile shaft. A clinical diagnosis of Bowenoid papulosis-like multiple condylomata of the groin was made. A 2-month imiquimod treatment did not induce any relevant improvement in terms of volume and number of lesions. A treatment with Polyphenon E, a topical green tea extract with 10% of EGCG (Veregen®), was therefore started. After 2 months of Polyphenon E treatment, a dramatic reduction of the majority of the lesions was observed. After 3 months of treatment, all the lesions disappeared with only hyperchromic residues. Histological and immunohistological findings supported seborrheic keratosis as the conclusive diagnosis. This case report suggests that topical green tea extract could be very effective in the treatment of “seborrheic keratosis-like” lesions of the inguinal area.
ISSN:1662-6567
1662-6567
DOI:10.1159/000503989