Intralesional Avirulent Bacillus Calmette-Guérin Injection as a Promising Method for the Treatment of Tuberculosis Verrucosa Cutis

Cutaneous involvement is a relatively uncommon manifestation of tuberculosis (TB), particularly outside the endemic regions. Cutaneous TB manifests itself in various clinical forms, depending on the host’s immune status and mode of transmission. Nonetheless, the same treatment regimen is recommended...

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Bibliographic Details
Published in:Case reports in dermatology 2022-01, Vol.14 (1), p.49-54
Main Authors: Gündüz, Özgür, Koçak, Gülşah, Kaçmaz, Birgül, Devrim, Tuba, Şimşek, Hülya
Format: Article
Language:English
Subjects:
bacillus calmette-guérin
Case reports
Drug dosages
Edema
Erythema
Granulomas
Immune system
Immunotherapy
Inflammation
Laboratories
Patients
Polymerase chain reaction
Single Case
Skin diseases
Tuberculosis
tuberculosis verrucosa cutis
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Summary:Cutaneous involvement is a relatively uncommon manifestation of tuberculosis (TB), particularly outside the endemic regions. Cutaneous TB manifests itself in various clinical forms, depending on the host’s immune status and mode of transmission. Nonetheless, the same treatment regimen is recommended for every subtype. Tuberculosis verrucosa cutis (TBVC) is a specific subgroup in which the affected persons are usually healthy adults who are vaccinated or exposed to mycobacteria during their occupational activities. These patients have the ability to launch a strong cellular immune reaction against mycobacteria. In this article, we present an elderly patient with a 4-year history of TBVC who was treated with intralesional injection of avirulent Bacillus Calmette-Guérin (BCG) and report our clinical observation on the inflammatory and healing process of the patient’s lesion following the intralesional BCG injection.
ISSN:1662-6567
1662-6567
DOI:10.1159/000523797