A Rare Case of Lambert-Eaton Myasthenia Syndrome Associated with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Literature

Abstract Introduction: Lambert-Eaton myasthenia syndrome (LEMS) is a rare autoimmune disorder characterized by autoantibodies targeting presynaptic neuromuscular junctions. It results in muscle weakness and autonomic dysfunction. LEMS can be idiopathic or associated with neoplastic diseases, often s...

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Bibliographic Details
Published in:Case reports in oncology 2023-01, Vol.16 (1), p.1300-1305
Main Authors: Abu-Tineh, Mohammad, Alamin, Mohammed A., Aljaloudi, Esra’a, Alshurafa, Awni, Garcia-Cañibano, Beatriz, Taha, Ruba Y., Elkourashy, Sarah A.
Format: Article
Language:English
Subjects:
Abdomen
Antibodies
Antigens
autoimmune disorders
Biopsy
Bone marrow
Cancer therapies
Case Report
Case reports
Chemotherapy
Conflicts of interest
Disease prevention
Drug dosages
Illnesses
lambert-eaton myasthenic syndrome
Lymphocytes
Lymphoma
Medical prognosis
non-hodgkin lymphoma
Patients
peripheral t-cell lymphoma
Remission (Medicine)
Sepsis
Tomography
Transplants & implants
Tumors
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Summary:Abstract Introduction: Lambert-Eaton myasthenia syndrome (LEMS) is a rare autoimmune disorder characterized by autoantibodies targeting presynaptic neuromuscular junctions. It results in muscle weakness and autonomic dysfunction. LEMS can be idiopathic or associated with neoplastic diseases, often small-cell lung cancer. This case report describes a rare instance of paraneoplastic LEMS in a man with non-Hodgkin lymphoma. Case Presentation: A 57-year-old male with non-Hodgkin lymphoma presented with progressive muscle weakness, diminished reflexes, and autonomic symptoms. Diagnosis revealed LEMS with autoantibodies against voltage-gated calcium channels. Immunosuppressive therapy and lymphoma treatment led to significant improvement in his condition. Conclusion: This case highlights the rare occurrence of paraneoplastic LEMS in a patient with non-Hodgkin lymphoma. Recognition and timely management of LEMS alongside lymphoma treatment can lead to significant clinical improvement, emphasizing the need for increased awareness of such complex associations.
ISSN:1662-6575
1662-6575
DOI:10.1159/000534557