Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults

Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function. Twenty-five healthy adults underwent a randomized, double-blind, crossover...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2002-04, Vol.105 (13), p.1534-1536
Main Authors: BROOK, Robert D, BROOK, Jeffrey R, URCH, Bruce, VINCENT, Renaud, RAJAGOPALAN, Sanjay, SILVERMAN, Frances
Format: Article
Language:English
Subjects:
Adult
Air
Air Pollutants - adverse effects
Air Pollutants - chemistry
Air Pollution - adverse effects
Arteries - diagnostic imaging
Arteries - physiology
Biological and medical sciences
Brachial Artery - physiology
Cross-Over Studies
Double-Blind Method
Environmental pollutants toxicology
Female
Humans
Inhalation Exposure
Male
Medical sciences
Ozone - administration & dosage
Ozone - adverse effects
Particle Size
Toxicology
Ultrasonography
Vasoconstriction
Vasodilation
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Summary:Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function. Twenty-five healthy adults underwent a randomized, double-blind, crossover study comparing the vascular response to the 2-hour inhalation of approximately 150 microg/m(3) of concentrated ambient fine particles (CAP) plus ozone (120 ppb) versus the response to the inhalation of filtered air. High-resolution vascular ultrasonography was used to measure alterations in brachial artery diameter, endothelial-dependent flow-mediated dilatation (FMD) and endothelial-independent nitroglycerin-mediated dilatation (NMD). Exposure to CAP plus ozone caused a significant brachial artery vasoconstriction compared with filtered air inhalation (-0.09+/-0.15 mm versus +0.01+/-0.18 mm, P=0.03). There were no significant differences in FMD (+0.29+/-4.11% versus -0.03+/-6.63%, P=0.88), NMD (+3.87+/-5.43% versus +3.46+/-7.92%, P=0.83), or blood pressure responses between exposures. Short-term inhalation of fine particulate air pollution and ozone at concentrations that occur in the urban environment causes acute conduit artery vasoconstriction.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.0000013838.94747.64