Stromal Cell–Derived Factor-1α Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of Injury

Background— After myocardial infarction (MI), bone marrow–derived cells (BMDCs) are found within the myocardium. The mechanisms determining BMDC recruitment to the heart remain unclear. We investigated the role of stromal cell–derived factor-1α (SDF-1) in this process. Methods and Results— MI produc...

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Published in:Circulation (New York, N.Y.) N.Y.), 2004-11, Vol.110 (21), p.3300-3305
Main Authors: Abbott, J. Dawn, Huang, Yan, Liu, Dingang, Hickey, Reed, Krause, Diane S., Giordano, Frank J.
Format: Article
Language:English
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Summary:Background— After myocardial infarction (MI), bone marrow–derived cells (BMDCs) are found within the myocardium. The mechanisms determining BMDC recruitment to the heart remain unclear. We investigated the role of stromal cell–derived factor-1α (SDF-1) in this process. Methods and Results— MI produced in mice by coronary ligation induced SDF-1 mRNA and protein expression in the infarct and border zone and decreased serum SDF-1 levels. By quantitative polymerase chain reaction, 48 hours after intravenous infusion of donor-lineage BMDCs, there were 80.5±15.6% more BDMCs in infarcted hearts compared with sham-operated controls ( P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000147780.30124.CF