Efficacy of dofetilide in the treatment of atrial fibrillation-flutter in patients with reduced left ventricular function : A Danish Investigations of Arrhythmia and Mortality ON Dofetilide (DIAMOND) substudy

In patients with left ventricular dysfunction, atrial fibrillation and flutter (AF and AFl, respectively) are common arrhythmias associated with increased morbidity and mortality. The present study investigated the potential of dofetilide in AF-AFl patients with left ventricular dysfunction to resto...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-07, Vol.104 (3), p.292-296
Main Authors: PEDERSEN, Ole D, BAGGER, Henning, KELLER, Niels, MARCHANT, Bradley, KØBER, Lars, TORP-PEDERSEN, Christian
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Aged
Aged, 80 and over
Anti-Arrhythmia Agents - administration & dosage
Anti-Arrhythmia Agents - adverse effects
Antiarythmic agents
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Atrial Fibrillation - mortality
Atrial Flutter - complications
Atrial Flutter - drug therapy
Atrial Flutter - mortality
Biological and medical sciences
Cardiovascular system
Chronic Disease
Denmark
Double-Blind Method
Female
Follow-Up Studies
Heart Failure - complications
Humans
Male
Medical sciences
Middle Aged
Myocardial Infarction - complications
Odds Ratio
Pharmacology. Drug treatments
Phenethylamines - administration & dosage
Phenethylamines - adverse effects
Sulfonamides - administration & dosage
Sulfonamides - adverse effects
Survival Rate
Treatment Outcome
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - drug therapy
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Description
Summary:In patients with left ventricular dysfunction, atrial fibrillation and flutter (AF and AFl, respectively) are common arrhythmias associated with increased morbidity and mortality. The present study investigated the potential of dofetilide in AF-AFl patients with left ventricular dysfunction to restore and maintain sinus rhythm, which might reduce mortality and hospitalizations. In the Danish Investigations of Arrhythmia and Mortality ON Dofetilide (DIAMOND) studies, 506 patients were in AF-AFl at baseline. Over the course of study, cardioversion occurred in 148 (59%) dofetilide- and 86 (34%) placebo-treated patients. In these patients, the probability of maintaining sinus rhythm for 1 year was 79% with dofetilide versus 42% with placebo (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.104.3.292