Myocardial perfusion scintigraphy after intracoronary injection of 99m Tc-labeled human albumin microspheres. Toxicity and efficacy for detecting myocardial infarction in dogs; preliminary results in man

Myocardial perfusion scintigraphy was performed in 30 intact anesthetized dogs following intracoronary injection of 99m Tc-labeled human albumin microspheres (HAM). The normal dog myocardial image pattern was established. This technic detected myocardial infarcts resulting from small vessel occlusio...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1972-11, Vol.46 (5), p.963-975
Main Authors: Weller, D A, Adolph, R J, Wellman, H N, Carroll, R G, Kim, O
Format: Article
Language:English
Subjects:
Adult
Albumins
Angiocardiography
Animals
Blood Pressure
Cardiac Catheterization
Coronary Circulation
Dogs
Electrocardiography
Female
Heart Function Tests
Heart Rate
Humans
Male
Microcirculation
Microspheres
Middle Aged
Myocardial Infarction - diagnosis
Perfusion
Radionuclide Imaging
Technetium
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Summary:Myocardial perfusion scintigraphy was performed in 30 intact anesthetized dogs following intracoronary injection of 99m Tc-labeled human albumin microspheres (HAM). The normal dog myocardial image pattern was established. This technic detected myocardial infarcts resulting from small vessel occlusions and flush coronary branch occlusions when the coronary angiogram appeared normal. Myocardial infarcts as small as 1½ cm were seen. Toxicologic studies in 47 dogs failed to demonstrate significant changes in blood pressure, heart rate, electrocardiogram, or serum CPK activity following intracoronary injections of HAM in doses up to 200 times that required for adequate myocardial scintigraphy. Gross and microscopic examination of hearts 1-6 weeks after HAM injection showed minor abnormalities also seen in matched controls receiving coronary arteriography alone. Preliminary results in 33 patients substantiate the safety of this technic. Human myocardial scintigrams reported here reveal anatomic detail not previously demonstrated by other external imaging methods.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.46.5.963