Dobutamine Echocardiography and Quantitative Rest-Redistribution 201 Tl Tomography in Myocardial Hibernation: Relation of Contractile Reserve to 201 Tl Uptake and Comparative Prediction of Recovery of Function

• Published in: Circulation (New York, N.Y.) N.Y.), 1997-02, Vol.95 (3), p.626-635
• Main Authors: Qureshi, Usman, Nagueh, Sherif F., Afridi, Imran, Vaduganathan, Periyanan, Blaustein, Alvin, Verani, Mario S., Winters, William L., Zoghbi, William A.
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.CIR.95.3.626

Background The purposes of this study were to evaluate the comparative accuracy of dobutamine echocardiography and quantitative rest-redistribution 201 Tl tomography in the prediction of recovery of function after revascularization and to assess the relation of contractile reserve to thallium uptake. Methods and Results Thirty-four patients with stable coronary disease and regional dysfunction underwent dobutamine echocardiography (2.5 up to 40 μg·kg −1 ·min −1 ) and rest-redistribution 201 Tl tomography 1 day before revascularization. Resting echocardiography and scintigraphy were repeated at ≥6 weeks. Before revascularization, resting 201 Tl uptake was similar in segments demonstrating biphasic or sustained improvement and was higher than in those exhibiting no change or worsening function during dobutamine. After revascularization, 201 Tl uptake increased only in segments that showed a biphasic response (from 66±12% to 78±13%; P