Increased Formation of Distinct F 2 Isoprostanes in Hypercholesterolemia

Background —F 2 isoprostanes are stable, free radical–catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results —Specific assays were developed by use of mass spectrometry for the F 2 isoprostanes iPF 2α -III and iPF 2α -VI and arachidonic acid (AA). Urinary...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1998-12, Vol.98 (25), p.2822-2828
Main Authors: Reilly, Muredach P., Praticò, Domenico, Delanty, Norman, DiMinno, Giovanni, Tremoli, Elena, Rader, Daniel, Kapoor, Shiv, Rokach, Joshua, Lawson, John, FitzGerald, Garret A.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background —F 2 isoprostanes are stable, free radical–catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results —Specific assays were developed by use of mass spectrometry for the F 2 isoprostanes iPF 2α -III and iPF 2α -VI and arachidonic acid (AA). Urinary excretion of the 2 F 2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF 2α -III (pmol/mmol creatinine) was elevated ( P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.98.25.2822