ET A Receptor Blockade Decreases Vascular Superoxide Generation in DOCA-Salt Hypertension

Development and progression of end-organ damage in hypertension have been associated with increased oxidative stress. Superoxide anion accumulation has been reported in deoxycorticosterone acetate (DOCA)-salt hypertension, in which endothelin-1 plays an important role in cardiovascular damage. We hy...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2003-10, Vol.42 (4), p.811-817
Main Authors: Callera, Glaucia E., Touyz, Rhian M., Teixeira, Simone A., Muscara, Marcelo N., Carvalho, Maria Helena C., Fortes, Zuleica B., Nigro, Dorothy, Schiffrin, Ernesto L., Tostes, Rita C.
Format: Article
Language:English
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Summary:Development and progression of end-organ damage in hypertension have been associated with increased oxidative stress. Superoxide anion accumulation has been reported in deoxycorticosterone acetate (DOCA)-salt hypertension, in which endothelin-1 plays an important role in cardiovascular damage. We hypothesized that blockade of ET A receptors in DOCA-salt rats would decrease oxidative stress. Both systolic blood pressure (SBP, 210±9 mm Hg; P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000088363.65943.6C