Lipid Bilayer in Genetic Hypertension

Membrane microviscosity, phospholipid composition, and turnover were measured in cultured vascular smooth muscle cells isolated from mesenteric arteries of stroke-prone spontaneously hypertensive and age-matched, normotensive Wistar-Kyoto rats. Membrane microviscosity, measured with fluorescence pol...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1991-12, Vol.18 (6), p.748-757
Main Authors: Dominiczak, Anna F, Lazar, Dan F, Das, Arun K, Bohr, David F
Format: Article
Language:English
Subjects:
Animals
Aorta
Biological and medical sciences
Blood and lymphatic vessels
Blood Platelets - chemistry
Calcium - pharmacology
Cardiology. Vascular system
Cell Membrane - chemistry
Cell Membrane - ultrastructure
Cells, Cultured
Hypertension - genetics
Hypertension - pathology
Medical sciences
Membrane Lipids - analysis
Membrane Lipids - metabolism
Mesenteric Arteries
Muscle, Smooth, Vascular - metabolism
Phosphatidic Acids - analysis
Phosphatidylcholines - analysis
Phosphatidylethanolamines - analysis
Phosphatidylinositols - analysis
Phosphatidylserines - analysis
Polarography
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Sphingomyelins - analysis
Viscosity - drug effects
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Summary:Membrane microviscosity, phospholipid composition, and turnover were measured in cultured vascular smooth muscle cells isolated from mesenteric arteries of stroke-prone spontaneously hypertensive and age-matched, normotensive Wistar-Kyoto rats. Membrane microviscosity, measured with fluorescence polarization, revealed greater microviscosity (lower fluidity) of the membranes isolated from smooth muscle cells from hypertensive as compared with those isolated from normotensive rats (p
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.18.6.748