NF-κB Inhibition Ameliorates Angiotensin II–Induced Inflammatory Damage in Rats

ABSTRACTWe recently reported that the activation of nuclear factor-κB (NF-κB) promotes inflammation in rats harboring both human renin and angiotensinogen genes (double-transgenic rats [dTGR]). We tested the hypothesis that the antioxidant pyrrolidine dithiocarbamate (PDTC) inhibits NF-κB and amelio...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-01, Vol.35 (1, Part 2 Suppl), p.193-193
Main Authors: Muller, Dominik N, Dechend, Ralf, Mervaala, Eero M. A, Park, Joon-Keun, Schmidt, Folke, Fiebeler, Anette, Theuer, Jürgen, Breu, Volker, Ganten, Detlev, Haller, Hermann, Luft, Friedrich C
Format: Article
Language:English
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Summary:ABSTRACTWe recently reported that the activation of nuclear factor-κB (NF-κB) promotes inflammation in rats harboring both human renin and angiotensinogen genes (double-transgenic rats [dTGR]). We tested the hypothesis that the antioxidant pyrrolidine dithiocarbamate (PDTC) inhibits NF-κB and ameliorates renal and cardiac end-organ damage. dTGR feature hypertension, severe renal and cardiac damage, and a 40% mortality rate at 7 weeks. Electrophoretic mobility shift assay showed increased NF-κB DNA binding activity in hearts and kidneys of dTGR. Chronic PDTC (200 mg/kg SC) treatment decreased blood pressure (162±8 versus 190±7 mm Hg;P =0.02) in dTGR compared with dTGR controls. The cardiac hypertrophy index was also significantly reduced (4.90±0.1 versus 5.77±0.1 mg/g;P 95% (2.5±0.8 versus 57.1±8.7 mg/d;P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.35.1.193